Friday, July 20, 2012

Computer Simulation of a Single-Celled Organism

Researchers at Stanford and at the J. Craig Ventner Institute announce the 'complete' simulation of a single organims. From the New York Times:
The simulation of the complete life cycle of the pathogen, Mycoplasma genitalium, was presented on Friday in the journal Cell. The scientists called it a “first draft” but added that the effort was the first time an entire organism had been modeled in such detail — in this case, all of its 525 genes. 
“Where I think our work is different is that we explicitly include all of the genes and every known gene function,” the team’s leader, Markus W. Covert, an assistant professor of bioengineering at Stanford, wrote in an e-mail. “There’s no one else out there who has been able to include more than a handful of functions or more than, say, one-third of the genes.” 
The simulation, which runs on a cluster of 128 computers, models the complete life span of the cell at the molecular level, charting the interactions of 28 categories of molecules — including DNA, RNA, proteins and small molecules known as metabolites that are generated by cell processes.

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